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Endothelial cell barrier protection by simvastatin: GTPase regulation and NADPH oxidase inhibition
The statins, hydroxy-3-methylglutaryl-CoA reductase inhibitors that lower serum cholesterol, exhibit myriad clinical benefits, including enhanced vascular integrity. One potential mechanism underlying increased endothelial cell (EC) barrier function is inhibition of geranylgeranylation, a covalent m...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2575942/ https://ncbi.nlm.nih.gov/pubmed/18658277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00428.2007 |
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