Binding of monoclonal antibody specific for domain Ia/II of Pseudomonas aeruginosa exotoxin A at pH 4 strongly neutralizes exotoxin A-induced cytotoxicity in cell culture and in vivo.

Mouse monoclonal antibodies (MAbs) against Pseudomonas aeruginosa exotoxin A (Ex-A) were established, and 4 of 20 MAbs were extensively studied for analysis of the structure-function relationship of Ex-A. IN vivo experiments demonstrated that MAb Ex-3C7 protected mice either injected with Ex-A or in...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Ohtsuka, H, Horigome, K, Higuchi, A, Nomura, N, Ochi, H, Yokota, S, Kohzuki, T, Noguchi, H
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1992
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC257594/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1371763/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.60.3.1061-1068.1992
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