Coordinated regulation of AP2 uncoating from clathrin-coated vesicles by rab5 and hRME-6

Here we investigate the role of rab5 and its cognate exchange factors rabex-5 and hRME-6 in the regulation of AP2 uncoating from endocytic clathrin-coated vesicles (CCVs). In vitro, we show that the rate of AP2 uncoating from CCVs is dependent on the level of functional rab5. In vivo, overexpression...

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Detalhes bibliográficos
Main Authors: Semerdjieva, Sophia, Shortt, Barry, Maxwell, Emma, Singh, Sukhdeep, Fonarev, Paul, Hansen, Jonathan, Schiavo, Giampietro, Grant, Barth D., Smythe, Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575790/
https://ncbi.nlm.nih.gov/pubmed/18981233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200806016
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