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The BH3-only protein Bik/Blk/Nbk inhibits nuclear translocation of activated ERK1/2 to mediate IFNγ-induced cell death

IFNγ induces cell death in epithelial cells, but the mediator for this death pathway has not been identified. In this study, we find that expression of Bik/Blk/Nbk is increased in human airway epithelial cells (AECs [HAECs]) in response to IFNγ. Expression of Bik but not mutant BikL61G induces and l...

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Detalles Bibliográficos
Main Authors: Mebratu, Yohannes A., Dickey, Burton F., Evans, Chris, Tesfaigzi, Yohannes
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575785/
https://ncbi.nlm.nih.gov/pubmed/18981230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200801186
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