Enhancement of cytotoxic T lymphocyte response in aged mice by a novel treatment with recombinant AdIL-12 and wild type adenovirus in rapid succession

A decrease in the expression of Th1 cytokines has been associated with age-related decrease in cytotoxic T lymphocyte (CTL) function. We utilized an E1-deleted adenovirus (Ad) vector to deliver the murine IL-12 (IL-12) gene in order to enhance the antivirus CTL response. Wild type (WT) Ad was admini...

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Main Authors: Chen, Jian, Wang, John, Li, Jun, Wu, Qi, Lim, Fei Chu, Yang, PingAr, Hsu, Hui-Chen, Curiel, David T., Mountz, John D.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575091/
https://ncbi.nlm.nih.gov/pubmed/18545221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.121
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