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n-Alcohols Inhibit Voltage-Gated Na(+) Channels Expressed in Xenopus Oocytes

Voltage-gated sodium channels are essential for the initiation and propagation of action potentials in excitable cells and are known as a target of local anesthetics. In addition, inhibition of sodium channels by volatile anesthetics has been proposed as a mechanism of general anesthesia. The n-alco...

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Detalhes bibliográficos
Main Authors: Horishita, Takafumi, Harris, R. Adron
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575017/
https://ncbi.nlm.nih.gov/pubmed/18434586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.138370
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