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Impaired differentiation and apoptosis of hematopoietic precursors in a mouse model of myelodysplastic syndrome

Expression of a NUP98-HOXD13 (NHD13) fusion gene, initially identified in a patient with myelodysplastic syndrome (MDS), leads to a highly penetrant MDS in mice that recapitulates all of the key features of the human disease. Expansion of undifferentiated lineage negative (lin(neg)) hematopoietic pr...

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Autors principals: Choi, Chul Won, Chung, Yang Jo, Slape, Christopher, Aplan, Peter D.
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575012/
https://ncbi.nlm.nih.gov/pubmed/18603548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.13042
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