Circadian distribution of generalized tonic–clonic seizures associated with murine succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism

Human succinic semialdehyde dehydrogenase (SSADH) deficiency is an autosomal recessive disorder of GABA metabolism associated with motor impairment and epileptic seizures. Similarly, mice with targeted deletion of the Aldh5a1 gene (Aldh5a1(−/−)) exhibit SSADH deficiency and seizures early in life. T...

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Hlavní autoři: Stewart, Lee S., Nylen, Kirk J., Persinger, Michael A., Cortez, Miguel A., Gibson, K. Michael, Snead, O. Carter
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574901/
https://ncbi.nlm.nih.gov/pubmed/18514581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yebeh.2008.04.012
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