INITIATION OF THE ALTERNATIVE PATHWAY OF COMPLEMENT BY IMMUNE COMPLEXES IS DEPENDENT ON N-GLYCANS IN IgG ANTIBODIES

OBJECTIVE: Collagen antibody-induced arthritis (CAIA) in mice exhibits a requirement for amplification by the alternative pathway (AP) of complement. Although the AP is activated by spontaneous hydrolysis, it is not known whether the AP can also be initiated directly by IgG antibodies in immune comp...

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Main Authors: Banda, Nirmal K., Wood, Allyson K., Takahashi, Kazue, Levitt, Brandt, Rudd, Pauline M., Royle, Louise, Abrahams, Jodie L., Stahl, Gregory L., Holers, V. Michael, Arend, William P.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574875/
https://ncbi.nlm.nih.gov/pubmed/18821684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.23865
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