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Synthesis and biological evaluation of 2-(3′,4′,5′-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization

Molecules that target microtubules have an important role in the treatment of cancer. A new class of inhibitors of tubulin polymerization based on the 2-(3,4,5-trimethoxybenzoyl)-2-dimethylamino-benzo[b]furan molecular skeleton was synthesized and evaluated for antiproliferative activity, inhibition...

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Detalhes bibliográficos
Main Authors: Romagnoli, Romeo, Baraldi, Pier Giovanni, Sarkar, Taradas, Carrion, Maria Dora, Cruz-Lopez, Olga, Cara, Carlota Lopez, Tolomeo, Manlio, Grimaudo, Stefania, Di Cristina, Antonietta, Pipitone, Maria Rosaria, Balzarini, Jan, Gambari, Roberto, Ilaria, Lampronti, Saletti, Roberto, Brancale, Andrea, Hamel, Ernest
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574800/
https://ncbi.nlm.nih.gov/pubmed/18755591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.08.029
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