Bi-functional CD22 ligands use multimeric immunoglobulins as protein scaffolds in assembly of immune complexes on B cells

CD22 is a B cell specific sialic-acid-binding immunoglobulin-like lectin (Siglec) whose function as a regulator of B cell signaling is modulated by its interaction with glycan ligands bearing the sequence NeuAcα2-6Gal. To date, only highly multivalent polymeric ligands (n=450) have achieved sufficie...

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Hlavní autoři: O'Reilly, Mary K., Collins, Brian E., Han, Shoufa, Liao, Liang, Rillahan, Cory, Kitov, Pavel I., Bundle, David R., Paulson, James C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574768/
https://ncbi.nlm.nih.gov/pubmed/18505252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja802008q
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