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Bi-functional CD22 ligands use multimeric immunoglobulins as protein scaffolds in assembly of immune complexes on B cells
CD22 is a B cell specific sialic-acid-binding immunoglobulin-like lectin (Siglec) whose function as a regulator of B cell signaling is modulated by its interaction with glycan ligands bearing the sequence NeuAcα2-6Gal. To date, only highly multivalent polymeric ligands (n=450) have achieved sufficie...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2574768/ https://ncbi.nlm.nih.gov/pubmed/18505252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja802008q |
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