Gamma-vinyl GABA inhibits cocaine-triggered reinstatement of drug-seeking behavior in rats by a non-dopaminergic mechanism

Relapse to drug use is a core feature of addiction. Previous studies demonstrate that γ-vinyl GABA (GVG), an irreversible GABA transaminase inhibitor, attenuates the acute rewarding effects of cocaine and other addictive drugs. We here report that systemic administration of GVG (25–300 mg/kg) dose-d...

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Autors principals: Peng, Xiao-Qing, Li, Xia, Gilbert, Jeremy G., Pak, Arlene C., Ashby, Charles R., Brodie, Jonathan D., Dewey, Stephen L., Gardner, Eliot L., Xi, Zheng-Xiong
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574671/
https://ncbi.nlm.nih.gov/pubmed/18063319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drugalcdep.2007.10.004
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