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DNA damage and homologous recombination signaling induced by thymidylate deprivation
DNA damage is accepted as a consequence of thymidylate deprivation induced by chemotherapeutic inhibitors of thymidylate synthase (TS), but the types of damage and signaling responses remain incompletely understood. Thymidylate deprivation increases dUTP and uracil in DNA, which is removed by Base E...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2574569/ https://ncbi.nlm.nih.gov/pubmed/18773878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2008.08.010 |
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