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DNA damage and homologous recombination signaling induced by thymidylate deprivation

DNA damage is accepted as a consequence of thymidylate deprivation induced by chemotherapeutic inhibitors of thymidylate synthase (TS), but the types of damage and signaling responses remain incompletely understood. Thymidylate deprivation increases dUTP and uracil in DNA, which is removed by Base E...

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Bibliografski detalji
Glavni autori: Yang, Zhengguan, Waldman, Alan S., Wyatt, Michael D.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574569/
https://ncbi.nlm.nih.gov/pubmed/18773878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2008.08.010
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