SCID-Hu mice immunized with a pneumococcal vaccine produce specific human antibodies and show increased resistance to infection.

Seventy-eight severe combined immunodeficiency (SCID) mice were administered intraperitoneally 1 x 10(7) to 9 x 10(7) human peripheral blood mononuclear cells (PBL) in five experiments. Human immunoglobulin G (IgG) was detected in 70 to 88% of these SCID-PBL-Hu mice after cell transplantation, and a...

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Autori principali: Aaberge, I S, Michaelsen, T E, Rolstad, A K, Groeng, E C, Solberg, P, Løvik, M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1992
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC257447/
https://ncbi.nlm.nih.gov/pubmed/1398925
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