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SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability
Axin is a scaffold protein for the β-catenin destruction complex, and a negative regulator of canonical Wnt signaling. Previous studies implicated the six C-terminal amino acids (C6 motif) in the ability of Axin to activate c-Jun N-terminal kinase, and identified them as a SUMOylation target. Deleti...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Federation of American Societies for Experimental Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2574027/ https://ncbi.nlm.nih.gov/pubmed/18632848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-113910 |
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