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Chronic Antidiabetic Sulfonylureas In Vivo: Reversible Effects on Mouse Pancreatic β-Cells
BACKGROUND: Pancreatic β-cell ATP-sensitive potassium (K(ATP)) channels are critical links between nutrient metabolism and insulin secretion. In humans, reduced or absent β-cell K(ATP) channel activity resulting from loss-of-function K(ATP) mutations induces insulin hypersecretion. Mice with reduced...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2573909/ https://ncbi.nlm.nih.gov/pubmed/18959471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0050206 |
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