N88D Facilitates the Co-occurrence of D30N and L90M and the Development of Multidrug Resistance in HIV Type 1 Protease following Nelfinavir Treatment Failure

Nelfinavir was once one of the most commonly used protease inhibitors (PIs). To investigate the genetic mechanisms of multidrug resistance in protease isolates with the primary nelfinavir resistance mutation D30N, we analyzed patterns of protease mutations in 582 viruses with D30N from 460 persons u...

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Main Authors: MITSUYA, YUMI, WINTERS, MARK A., FESSEL, W. JEFFREY, RHEE, SOO-YON, HURLEY, LEO, HORBERG, MICHAEL, SCHIFFER, CELIA A., ZOLOPA, ANDREW R., SHAFER, ROBERT W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573402/
https://ncbi.nlm.nih.gov/pubmed/17209774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2006.22.1300
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