Defining Extracellular Integrin α-Chain Sites That Affect Cell Adhesion and Adhesion Strengthening without Altering Soluble Ligand Binding

It was previously shown that mutations of integrin α4 chain sites, within putative EF-hand-type divalent cation-binding domains, each caused a marked reduction in α4β1-dependent cell adhesion. Some reports have suggested that α-chain “EF-hand” sites may interact directly with ligands. However, we sh...

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Main Authors: Pujades, Cristina, Alon, Ronen, Yauch, Robert L., Masumoto, Akihide, Burkly, Linda C., Chen, Chun, Springer, Timothy A., Lobb, Roy R., Hemler, Martin E.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Cell Biology 1997
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC25734/
https://ncbi.nlm.nih.gov/pubmed/9398682
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