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The RNA Binding Protein hnRNP Q Modulates the Utilization of Exon 7 in the Survival Motor Neuron 2 (SMN2) Gene

Spinal muscular atrophy (SMA) is a recessive neuromuscular disorder caused by the homozygous loss of the SMN1 gene. The human SMN2 gene has a C-to-T transition at position +6 of exon 7 and thus produces exon 7-skipping mRNAs. However, we observed an unexpectedly high level of exon 7-containing SMN2...

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Bibliografiske detaljer
Main Authors: Chen, Hung-Hsi, Chang, Jan-Growth, Lu, Ruei-Min, Peng, Tsui-Yi, Tarn, Woan-Yuh
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573304/
https://ncbi.nlm.nih.gov/pubmed/18794368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01332-08
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