Evidence for Protection against Chronic Hepatitis C Virus Infection in Chimpanzees by Immunization with Replicating Recombinant Vaccinia Virus

Given the failures of nonreplicating vaccines against chronic hepatitis C virus (HCV) infection, we hypothesized that a replicating viral vector may provide protective immunity. Four chimpanzees were immunized transdermally twice with recombinant vaccinia viruses (rVV) expressing HCV genes. After ch...

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Detalhes bibliográficos
Main Authors: Youn, Jin-Won, Hu, Yu-Wen, Tricoche, Nancy, Pfahler, Wolfram, Shata, Mohamed Tarek, Dreux, Marlene, Cosset, François-Loic, Folgori, Antonella, Lee, Dong-Hun, Brotman, Betsy, Prince, Alfred M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573201/
https://ncbi.nlm.nih.gov/pubmed/18753204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01179-08
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