Biological activity of synthetic phosphonooxyethyl analogs of lipid A and lipid A partial structures.

We investigated the biological activity of four new synthetic analogs of lipid A, termed PE-1, PE-2, PE-3, and PE-4. All compounds contain an alpha-oxyethyl-linked (-O-CH2-CH2-) phosphoryl group in position 1 of the reducing glucosaminyl residue (GlcN I) of lipid A. PE-1 is a hexaacylated analog of...

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Detalles Bibliográficos

Publicado en:	Infect Immun
Autores principales:	Ulmer, A J, Heine, H, Feist, W, Kusumoto, S, Kusama, T, Brade, H, Schade, U, Rietschel, E T, Flad, H D
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1992
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC257316/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1639498/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.60.8.3309-3314.1992
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