Biological activity of synthetic phosphonooxyethyl analogs of lipid A and lipid A partial structures.

We investigated the biological activity of four new synthetic analogs of lipid A, termed PE-1, PE-2, PE-3, and PE-4. All compounds contain an alpha-oxyethyl-linked (-O-CH2-CH2-) phosphoryl group in position 1 of the reducing glucosaminyl residue (GlcN I) of lipid A. PE-1 is a hexaacylated analog of...

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Detalhes bibliográficos
Main Authors: Ulmer, A J, Heine, H, Feist, W, Kusumoto, S, Kusama, T, Brade, H, Schade, U, Rietschel, E T, Flad, H D
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC257316/
https://ncbi.nlm.nih.gov/pubmed/1639498
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