Plasmodium falciparum Strains Harboring Dihydrofolate Reductase with the I164L Mutation Are Absent in Malawi and Zambia Even under Antifolate Drug Pressure

The Plasmodium falciparum dihydrofolate reductase (PfDHFR) enzyme is the target of pyrimethamine, a component of the antimalarial pyrimethamine-sulfadoxine. Resistance to this drug is associated primarily with mutations in the Pfdhfr gene. The I164L mutant allele is of particular interest, because s...

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Autors principals: Ochong, Edwin, Bell, David J., Johnson, David J., D'Alessandro, Umberto, Mulenga, Modest, Muangnoicharoen, Sant, Van Geertruyden, Jean-Pierre, Winstanley, Peter A., Bray, Patrick G., Ward, Stephen A., Owen, Andrew
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573156/
https://ncbi.nlm.nih.gov/pubmed/18725445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00431-08
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