Up-regulating Sphingosine 1-Phosphate Receptor-2 Signaling Impairs Chemotactic, Wound-healing, and Morphogenetic Responses in Senescent Endothelial Cells

Vascular endothelial cells (ECs) have a finite lifespan when cultured in vitro and eventually enter an irreversible growth arrest state called “cellular senescence.” It has been shown that sphingolipids may be involved in senescence; however, the molecular links involved are poorly understood. In th...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Estrada, Rosendo, Zeng, Qun, Lu, Hongwei, Sarojini, Harshini, Lee, Jen-Fu, Mathis, Steven P., Sanchez, Teresa, Wang, Eugenia, Kontos, Christopher D., Lin, Chen-Yong, Hla, Timothy, Haribabu, Bodduluri, Lee, Menq-Jer
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2008
विषय:
Mechanisms of Signal Transduction
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573088/
https://ncbi.nlm.nih.gov/pubmed/18765664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804392200
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