Aptamer-based endocytosis of a lysosomal enzyme

Enzyme replacement therapy for lysosomal storage diseases is currently based on endocytosis of lysosomal enzymes via the mannose or mannose 6-phosphate receptors. We are developing a technology for endocytosis of lysosomal enzymes that depends on generic, chemically conjugated reagents. These reagen...

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Bibliographische Detailangaben
Hauptverfasser: Chen, Chi-hong B., Dellamaggiore, Kenneth R., Ouellette, Christopher P., Sedano, Cecilia D., Lizadjohry, Meikana, Chernis, George A., Gonzales, Michelle, Baltasar, Francis E., Fan, Audrey L., Myerowitz, Rachel, Neufeld, Elizabeth F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572987/
https://ncbi.nlm.nih.gov/pubmed/18838694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808360105
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