Aptamer-based endocytosis of a lysosomal enzyme

Enzyme replacement therapy for lysosomal storage diseases is currently based on endocytosis of lysosomal enzymes via the mannose or mannose 6-phosphate receptors. We are developing a technology for endocytosis of lysosomal enzymes that depends on generic, chemically conjugated reagents. These reagen...

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Detaylı Bibliyografya
Asıl Yazarlar: Chen, Chi-hong B., Dellamaggiore, Kenneth R., Ouellette, Christopher P., Sedano, Cecilia D., Lizadjohry, Meikana, Chernis, George A., Gonzales, Michelle, Baltasar, Francis E., Fan, Audrey L., Myerowitz, Rachel, Neufeld, Elizabeth F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2008
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572987/
https://ncbi.nlm.nih.gov/pubmed/18838694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808360105
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