Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity

Aire induces ectopic expression of peripheral tissue antigens (PTAs) in thymic medullary epithelial cells, which promotes immunological tolerance. Beginning with a broad screen of histone peptides, we demonstrate that the mechanism by which this single factor controls the transcription of thousands...

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Autors principals: Koh, Andrew S., Kuo, Alex J., Park, Sang Youn, Cheung, Peggie, Abramson, Jakub, Bua, Dennis, Carney, Dylan, Shoelson, Steven E., Gozani, Or, Kingston, Robert E., Benoist, Christophe, Mathis, Diane
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572939/
https://ncbi.nlm.nih.gov/pubmed/18840680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808470105
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