Rational attenuation of Corynebacterium pseudotuberculosis: potential cheesy gland vaccine and live delivery vehicle.

The phospholipase D (PLD) gene (pld) has been deleted from the Corynebacterium pseudotuberculosis chromosome by using site-specific mutagenesis. Sheep infection trials indicate that the PLD-negative C. pseudotuberculosis strain (Toxminus) is incapable of inducing caseous lymphadentis (cheesy gland)...

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Veröffentlicht in:	Infect Immun
Hauptverfasser:	Hodgson, A L, Krywult, J, Corner, L A, Rothel, J S, Radford, A J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1992
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC257252/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1612756/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.60.7.2900-2905.1992
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