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Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity
Anaphase-promoting complex/cyclosome (APC/C), an E3 ubiquitin ligase that destabilizes cell cycle proteins, is activated by Cdh1 in post-mitotic neurons, where it regulates axonal growth, synaptic plasticity and survival. The APC/C–Cdh1 substrate, cyclin B1, has been found to accumulate in degenerat...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2572178/ https://ncbi.nlm.nih.gov/pubmed/18818692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.195 |
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