TGFβ-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2

Transforming growth factor-β (TGFβ) induces the expression of the pro-apoptotic protein BIM, and mediates apoptosis in hepatocytes and B lymphocytes. BIM is regulated through a post-translational mechanism involving ERK-dependent phosphorylation and ubiquitin-mediated proteasomal degradation. Here,...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Ramesh, Sneha, Qi, Xiao-Jun, Wildey, Gary M, Robinson, Janet, Molkentin, Jeffery, Letterio, John, Howe, Philip H
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2008
Gaiak:
Scientific Report
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572119/
https://ncbi.nlm.nih.gov/pubmed/18704116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.158
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