Macaques vaccinated with live-attenuated SIV control replication of heterologous virus

An effective AIDS vaccine will need to protect against globally diverse isolates of HIV. To address this issue in macaques, we administered a live-attenuated simian immunodeficiency virus (SIV) vaccine and challenged with a highly pathogenic heterologous isolate. Vaccinees reduced viral replication...

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Bibliographic Details
Main Authors: Reynolds, Matthew R., Weiler, Andrea M., Weisgrau, Kim L., Piaskowski, Shari M., Furlott, Jessica R., Weinfurter, Jason T., Kaizu, Masahiko, Soma, Taeko, León, Enrique J., MacNair, Caitlin, Leaman, Dan P., Zwick, Michael B., Gostick, Emma, Musani, Solomon K., Price, David A., Friedrich, Thomas C., Rakasz, Eva G., Wilson, Nancy A., McDermott, Adrian B., Boyle, Rosanne, Allison, David B., Burton, Dennis R., Koff, Wayne C., Watkins, David I.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2571929/
https://ncbi.nlm.nih.gov/pubmed/18838548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081524
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