Amplification of HER2 is a marker for global genomic instability

BACKGROUND: Genomic alterations of the proto-oncogene c-erbB-2 (HER-2/neu) are associated with aggressive behavior and poor prognosis in patients with breast cancer. The variable clinical outcomes seen in patients with similar HER2 status, given similar treatments, suggests that the effects of ampli...

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Huvudupphovsmän: Ellsworth, Rachel E, Ellsworth, Darrell L, Patney, Heather L, Deyarmin, Brenda, Love, Brad, Hooke, Jeffrey A, Shriver, Craig D
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2008
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2571108/
https://ncbi.nlm.nih.gov/pubmed/18854030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-297
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