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AMP-Activated Protein Kinase-Regulated Activation of the PGC-1α Promoter in Skeletal Muscle Cells

The mechanisms by which PGC-1α gene expression is controlled in skeletal muscle remains largely undefined. Thus, we sought to investigate the transcriptional regulation of PGC-1α using AICAR, an activator of AMPK, that is known to increase PGC-1α expression. A 2.2 kb fragment of the human PGC-1α pro...

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Autors principals: Irrcher, Isabella, Ljubicic, Vladimir, Kirwan, Angie F., Hood, David A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570798/
https://ncbi.nlm.nih.gov/pubmed/18974883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003614
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