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The Histoplasma capsulatum Vacuolar ATPase is Required for Iron Homeostasis, Intracellular Replication in Macrophages, and Virulence in a Murine Model of Histoplasmosis

Histoplasma capsulatum is a dimorphic fungal pathogen that survives and replicates within macrophages (Mϕ). To identify specific genes required for intracellular survival, we utilized Agrobacterium tumefaciens-mediated mutagenesis, and screened for H. capsulatum insertional mutants that were unable...

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Autors principals: Hilty, Jeremy, Smulian, A. George, Newman, Simon L.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570752/
https://ncbi.nlm.nih.gov/pubmed/18699866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2008.06395.x
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