Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Pigs

Almost two decades after identification of the CFTR gene, we lack answers to many questions about the pathogenesis of cystic fibrosis (CF), and it remains a lethal disease. Mice with a disrupted CFTR gene have greatly facilitated CF studies, but they fail to develop the characteristic pancreatic, lu...

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Main Authors: Rogers, Christopher S., Stoltz, David A., Meyerholz, David K., Ostedgaard, Lynda S., Rokhlina, Tatiana, Taft, Peter J., Rogan, Mark P., Pezzulo, Alejandro A., Karp, Philip H., Itani, Omar A., Kabel, Amanda C., Wohlford-Lenane, Christine L., Davis, Greg J., Smith, Tony L., Samuel, Melissa, Wax, David, Murphy, Clifton N., Rieke, August, Whitworth, Kristin, Uc, Aliye, Starner, Timothy D., Brogden, Kim A., Shilyansky, Joel, McCray, Paul B., Zabner, Joseph, Prather, Randall S., Welsh, Michael J.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570747/
https://ncbi.nlm.nih.gov/pubmed/18818360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1163600
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