Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Pigs

Almost two decades after identification of the CFTR gene, we lack answers to many questions about the pathogenesis of cystic fibrosis (CF), and it remains a lethal disease. Mice with a disrupted CFTR gene have greatly facilitated CF studies, but they fail to develop the characteristic pancreatic, lu...

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Bibliografiska uppgifter
Huvudupphovsmän: Rogers, Christopher S., Stoltz, David A., Meyerholz, David K., Ostedgaard, Lynda S., Rokhlina, Tatiana, Taft, Peter J., Rogan, Mark P., Pezzulo, Alejandro A., Karp, Philip H., Itani, Omar A., Kabel, Amanda C., Wohlford-Lenane, Christine L., Davis, Greg J., Smith, Tony L., Samuel, Melissa, Wax, David, Murphy, Clifton N., Rieke, August, Whitworth, Kristin, Uc, Aliye, Starner, Timothy D., Brogden, Kim A., Shilyansky, Joel, McCray, Paul B., Zabner, Joseph, Prather, Randall S., Welsh, Michael J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570747/
https://ncbi.nlm.nih.gov/pubmed/18818360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1163600
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