Lack of association of functional CTLA4 polymorphisms with juvenile idiopathic arthritis

OBJECTIVES: Juvenile idiopathic arthritis (JIA) is an autoimmune disorder mediated by Th1-immune responses. Cytotoxic T-lymphocyte Antigen 4 (CTLA4), expressed on the T-cell surface, plays a negative role in regulating T-cell activation. Single nucleotide polymorphisms (SNPs) in CTLA4 have been impl...

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Hlavní autoři: Prahalad, Sampath, Bohnsack, John F., Whiting, April, Clifford, Bronte, Jorde, Lynn B., Guthery, Stephen L., Thompson, Susan D., Glass, David N., Bamshad, Michael J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570539/
https://ncbi.nlm.nih.gov/pubmed/18576317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.23602
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