Liposomal encapsulation enhances the antitumour efficacy of the vascular disrupting agent ZD6126 in murine B16.F10 melanoma

Vascular disrupting agents (VDAs) are able to affect selectively tumour endothelial cell morphology resulting in vessel occlusion and widespread tumour cell necrosis. However, single-agent antitumour activity of VDAs is typically limited, as tumour regrowth occurs rapidly following drug treatment. T...

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Detalhes bibliográficos
Main Authors: Fens, M H A M, Hill, K J, Issa, J, Ashton, S E, Westwood, F R, Blakey, D C, Storm, G, Ryan, A J, Schiffelers, R M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570501/
https://ncbi.nlm.nih.gov/pubmed/18797467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604675
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