Small Interfering RNA–Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture

OBJECTIVE—Islet amyloid, formed by aggregation of the β-cell peptide islet amyloid polypeptide (IAPP; amylin), is a pathological characteristic of pancreatic islets in type 2 diabetes. Toxic IAPP aggregates likely contribute to the progressive loss of β-cells in this disease. We used cultured human...

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Detalhes bibliográficos
Main Authors: Marzban, Lucy, Tomas, Alejandra, Becker, Thomas C., Rosenberg, Lawrence, Oberholzer, Jose, Fraser, Paul E., Halban, Philippe A., Verchere, C. Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2008
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570401/
https://ncbi.nlm.nih.gov/pubmed/18694973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0485
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