Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors

A structure-activity relationship study of dorsomorphin, a previously identified inhibitor of SMAD 1/5/8 phosphorylation by bone morphogenetic protein (BMP) type 1 receptors ALK2, 3, and 6, revealed that increased inhibitory activity could be accomplished by replacing the pendent 4-pyridine ring wit...

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Main Authors: Cuny, Gregory D., Yu, Paul B., Laha, Joydev K., Xing, Xuechao, Liu, Ji-Feng, Lai, Carol S., Deng, Donna Y., Sachidanandan, Chetana, Bloch, Kenneth D., Peterson, Randall T.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570262/
https://ncbi.nlm.nih.gov/pubmed/18621530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.06.052
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