Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism

Bone morphogenetic protein (BMP) signals coordinate developmental patterning and have essential physiological roles in mature organisms. Here we describe the first known small-molecule inhibitor of BMP signaling—dorsomorphin, which we identified in a screen for compounds that perturb dorsoventral ax...

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Detalhes bibliográficos
Main Authors: Yu, Paul B, Hong, Charles C, Sachidanandan, Chetana, Babitt, Jodie L, Deng, Donna Y, Hoyng, Stefan A, Lin, Herbert Y, Bloch, Kenneth D, Peterson, Randall T
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727650/
https://ncbi.nlm.nih.gov/pubmed/18026094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2007.54
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