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Pro-NGF secreted by astrocytes promotes motor neuron cell death
It is well established that motor neurons depend for their survival on many trophic factors. In this study, we show that the precursor form of NGF (proNGF) can induce the death of motor neurons via engagement of the p75 neurotrophin receptor. The pro-apoptotic activity was dependent upon the presenc...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2570110/ https://ncbi.nlm.nih.gov/pubmed/17188890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2006.11.005 |
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