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Ceramide inhibits CCN2 expression in fibroblasts
Connective tissue growth factor (CTGF, CCN2) is induced in response to TGFβ in fibroblasts. In this report, we show that C2 ceramide reduced the ability of TGFβ to induce CCN2 protein, mRNA and promoter activity in fibroblasts. C2 ceramide reduced the ability of TGFβ to induce the generic Smad respo...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Springer Netherlands
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2570009/ https://ncbi.nlm.nih.gov/pubmed/18649016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12079-008-0024-4 |
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