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Ceramide inhibits CCN2 expression in fibroblasts

Connective tissue growth factor (CTGF, CCN2) is induced in response to TGFβ in fibroblasts. In this report, we show that C2 ceramide reduced the ability of TGFβ to induce CCN2 protein, mRNA and promoter activity in fibroblasts. C2 ceramide reduced the ability of TGFβ to induce the generic Smad respo...

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Autors principals: Kennedy, Laura, Parapuram, Sunil, Greenspoon, Jill, Leask, Andrew
Format: Artigo
Idioma:Inglês
Publicat: Springer Netherlands 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570009/
https://ncbi.nlm.nih.gov/pubmed/18649016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12079-008-0024-4
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