FUNCTIONAL ROLES FOR THE STRIATAL-ENRICHED TRANSCRIPTION FACTOR, BCL11B, IN THE CONTROL OF STRIATAL GENE EXPRESSION AND TRANSCRIPTIONAL DYSREGULATION IN HUNTINGTON'S DISEASE

Transcriptional dysregulation has emerged as a central pathogenic mechanism in Huntington's disease (HD), which is associated with neuropathological changes predominantly in the striatum. Here we demonstrate that expression of Bcl11b (a.k.a. CTIP2), a transcription factor exhibiting highly-enri...

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Bibliographic Details
Main Authors: Desplats, Paula A., Lambert, James R., Thomas, Elizabeth A.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2569875/
https://ncbi.nlm.nih.gov/pubmed/18595722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2008.05.005
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