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Mating Type Influences Chromosome Loss and Replicative Senescence in Telomerase Deficient Budding Yeast by Dnl4-dependent Telomere Fusion
As we age, the majority of our cells gradually lose the capacity to divide because of replicative senescence that results from the inability to replicate the ends of chromosomes. The timing of senescence is dependent on the length of telomeric DNA, which elicits a checkpoint signal when critically s...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2569869/ https://ncbi.nlm.nih.gov/pubmed/18627461 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2008.06353.x |
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