Differential regulation of morphine antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice

BACKGROUND: Mice lacking the preproenkephalin (ppENK) gene are hyperalgesic and show more anxiety and aggression than wild-type (WT) mice. The marked behavioral changes in ppENK knock-out (KO) mice appeared to occur in supraspinal response to painful stimuli. However the functional role of enkephali...

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Hauptverfasser: Chen, Tsung-Chieh, Cheng, Ying-Ying, Sun, Wei-Zen, Shyu, Bai-Chuang
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2008
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2569012/
https://ncbi.nlm.nih.gov/pubmed/18826595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-4-41
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