(-)-Epigallocatechin Gallate Regulates CD3-mediated T Cell Receptor Signaling in Leukemia through the Inhibition of ZAP-70 Kinase

The ζ chain-associated 70-kDa protein (ZAP-70) of tyrosine kinase plays a critical role in T cell receptor-mediated signal transduction and the immune response. A high level of ZAP-70 expression is observed in leukemia, which suggests ZAP-70 as a logical target for immunomodulatory therapies. (-)-Ep...

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Bibliografiske detaljer
Main Authors: Shim, Jung-Hyun, Choi, Hong Seok, Pugliese, Angelo, Lee, Sung-Young, Chae, Jung-Il, Choi, Bu Young, Bode, Ann M., Dong, Zigang
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568917/
https://ncbi.nlm.nih.gov/pubmed/18687687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802200200
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