(-)-Epigallocatechin Gallate Regulates CD3-mediated T Cell Receptor Signaling in Leukemia through the Inhibition of ZAP-70 Kinase

The ζ chain-associated 70-kDa protein (ZAP-70) of tyrosine kinase plays a critical role in T cell receptor-mediated signal transduction and the immune response. A high level of ZAP-70 expression is observed in leukemia, which suggests ZAP-70 as a logical target for immunomodulatory therapies. (-)-Ep...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Shim, Jung-Hyun, Choi, Hong Seok, Pugliese, Angelo, Lee, Sung-Young, Chae, Jung-Il, Choi, Bu Young, Bode, Ann M., Dong, Zigang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568917/
https://ncbi.nlm.nih.gov/pubmed/18687687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802200200
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados