Gene Disruption of Plasmodium falciparum p52 Results in Attenuation of Malaria Liver Stage Development in Cultured Primary Human Hepatocytes

Difficulties with inducing sterile and long lasting protective immunity against malaria with subunit vaccines has renewed interest in vaccinations with attenuated Plasmodium parasites. Immunizations with sporozoites that are attenuated by radiation (RAS) can induce strong protective immunity both in...

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Detalhes bibliográficos
Main Authors: van Schaijk, Ben C. L., Janse, Chris J., van Gemert, Geert-Jan, van Dijk, Melissa R., Gego, Audrey, Franetich, Jean-Francois, van de Vegte-Bolmer, Marga, Yalaoui, Samir, Silvie, Olivier, Hoffman, Stephen L., Waters, Andrew P., Mazier, Dominique, Sauerwein, Robert W., Khan, Shahid M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568858/
https://ncbi.nlm.nih.gov/pubmed/18958160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003549
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