Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release

Neurotransmitter release from presynaptic nerve terminals is regulated by soluble NSF attachment protein receptor (SNARE) complex–mediated synaptic vesicle fusion. Tomosyn inhibits SNARE complex formation and neurotransmitter release by sequestering syntaxin-1 through its C-terminal vesicle-associat...

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Detalhes bibliográficos
Main Authors: Sakisaka, Toshiaki, Yamamoto, Yasunori, Mochida, Sumiko, Nakamura, Michiko, Nishikawa, Kouki, Ishizaki, Hiroyoshi, Okamoto-Tanaka, Miki, Miyoshi, Jun, Fujiyoshi, Yoshinori, Manabe, Toshiya, Takai, Yoshimi
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568027/
https://ncbi.nlm.nih.gov/pubmed/18936251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200805150
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