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Valproic Acid Induced Fetal Malformations Are Reduced by Maternal Immune Stimulation with Granulocyte-Macrophage Colony-Stimulating Factor or Interferon γ

Valproic acid, a drug commonly used to treat seizures and other psychiatric disorders, causes neural tube defects (NTDs) in exposed fetuses at a rate 20 times higher than in the general population. Failure of the neural tube to close during development, results in exencephaly or anencephaly, and spi...

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Autors principals: Hrubec, Terry C., Yan, Mingjin, Ye, Keying, Salafia, Carolyn M., Holladay, Steven D.
Format: Artigo
Idioma:Inglês
Publicat: 2006
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567843/
https://ncbi.nlm.nih.gov/pubmed/17075842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ar.a.20397
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