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Preneoplastic lesion growth driven by the death of adjacent normal stem cells

Clonal expansion of premalignant lesions is an important step in the progression to cancer. This process is commonly considered to be a consequence of sustaining a proliferative mutation. Here, we investigate whether the growth trajectory of clones can be better described by a model in which clone g...

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Autores principales: Chao, Dennis L., Eck, J. Thomas, Brash, Douglas E., Maley, Carlo C., Luebeck, E. Georg
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567488/
https://ncbi.nlm.nih.gov/pubmed/18815380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802211105
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